Set in the late 19th century, this surreal Italian-American anti-Western follows Rosa and her lover, the outlaw-turned-folk-hero Santino, as they flee across the Italian wilderness after a deadly confrontation, pursued by an American showman (John C. Reilly). As their tale grows into a legend, it transforms into a whimsical, and sometimes ghostly journey that merges local folklore with the myth of the American Wild West.